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Table 3 10-year mathematics SNP and SNP-set associations with reading and general cognitive ability.

From: Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities

  g at 10 Teacher reading at 10 Web reading at 10
  Cor N Cor N Cor N
rs11225308 0.056* 1661 0.056** 1819 0.042* 1858
rs363449 0.032 1645 0.071** 1827 0.047* 1845
rs17278234 0.023 1650 0.033 1830 0.060** 1850
10-SNP set 0.121** 1431 0.118** 1576 0.110** 1609
43-SNP set 0.107** 1436 0.137** 1578 0.101** 1613
r p 0.596** 1762 0.673** 1971 0.517** 1953
  1. Association was assessed with rs11225308, rs363449, rs17278234, and the 10- and 43-SNP sets previously associated with mathematics at age 10. Associations are presented as correlations between the quantitative traits and additive genotypic values (as 0, 1, and 2 'increasing' alleles) for SNPs and additive SNP scores for SNP sets. G at 10 = general cognitive ability at age 10; Teacher reading at 10 = NC-based teacher-ratings of reading ability at age 10; Web reading at 10 = performance on web-administered tests of reading at age 10; Cor = Pearson product moment correlations (p-values in italics); N = size of sample analysed; r p = phenotypic correlation with mathematic composite score at age 10. One-tailed p-values were generated for all SNP-associations. * = nominally significant associations (p < 0.05). ** = associations withstanding Bonferroni testing for the five (three individual SNP and two SNP-set) association tests conducted simultaneously for each measure (p < 0.01).