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Table 3 10-year mathematics SNP and SNP-set associations with reading and general cognitive ability.

From: Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities

 

g at 10

Teacher reading at 10

Web reading at 10

 

Cor

N

Cor

N

Cor

N

rs11225308

0.056*

1661

0.056**

1819

0.042*

1858

rs363449

0.032

1645

0.071**

1827

0.047*

1845

rs17278234

0.023

1650

0.033

1830

0.060**

1850

10-SNP set

0.121**

1431

0.118**

1576

0.110**

1609

43-SNP set

0.107**

1436

0.137**

1578

0.101**

1613

r p

0.596**

1762

0.673**

1971

0.517**

1953

  1. Association was assessed with rs11225308, rs363449, rs17278234, and the 10- and 43-SNP sets previously associated with mathematics at age 10. Associations are presented as correlations between the quantitative traits and additive genotypic values (as 0, 1, and 2 'increasing' alleles) for SNPs and additive SNP scores for SNP sets. G at 10 = general cognitive ability at age 10; Teacher reading at 10 = NC-based teacher-ratings of reading ability at age 10; Web reading at 10 = performance on web-administered tests of reading at age 10; Cor = Pearson product moment correlations (p-values in italics); N = size of sample analysed; r p = phenotypic correlation with mathematic composite score at age 10. One-tailed p-values were generated for all SNP-associations. * = nominally significant associations (p < 0.05). ** = associations withstanding Bonferroni testing for the five (three individual SNP and two SNP-set) association tests conducted simultaneously for each measure (p < 0.01).