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Table 2 10-year mathematics SNP and SNP-set associations with mathematical ability at ages 7, 9 and 12.

From: Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities

  Teacher mathematics at 7 Teacher mathematics at 9 Teacher mathematics at 12 Web mathematics at 12
  Cor N Cor N Cor N Cor N
rs11225308 0.019 3869 0.058** 1713 0.012 2213 0.025 3115
rs363449 0.016 3885 0.062** 1703 0.001 2223 0.018 3123
rs17278234 0.028* 3891 0.054* 1708 0.031 2227 -0.007 3132
10-SNP set 0.046** 3348 0.096** 1480 0.025 1922 0.036* 2691
43-SNP set 0.046** 3357 0.090** 1483 0.052* 1927 0.060** 2695
r p 0.594** 1979 0.633** 1632 0.566** 916 0.636** 1690
  1. Association was assessed with rs11225308, rs363449, rs17278234, and the 10- and 43-SNP sets previously associated with mathematics at age 10. Associations are presented as correlations between the quantitative traits and additive genotypic values (as 0, 1, and 2 'increasing' alleles) for SNPs and additive SNP scores for SNP sets. Teacher mathematics at 7 = NC-based teacher-ratings of mathematical ability at age 7; Teacher mathematics at 9 = NC-based teacher-ratings of mathematical ability at age p; Web mathematics at 12 = performance on web-administered tests of mathematical ability at age 12; Teacher mathematics at 12 = NC-based teacher-ratings of mathematical ability at age 12; Cor = Pearson product moment correlations (p-values in italics); N = size of sample analysed; r p = phenotypic correlation with mathematic composite score at age 10. One-tailed p-values were generated for all SNP-associations. * = nominally significant associations (p < 0.05). ** = associations withstanding Bonferroni testing for the five (three individual SNP and two SNP-set) association tests conducted simultaneously for each measure (p < 0.01).
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