PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs

BMC Genomic Data

Table 5 Armitage trend tests on nine OPRM1 SNPs and heroin-induced positive responses on first use

SNP	Genotype	Count and frequency				Armitage trend test
		Cases		Controls		Chi-square	P -value
rs1799971	AA	55	0.604	150	0.622	0.003	0.9537
	AG	27	0.297	64	0.266
	GG	9	0.099	24	0.112
rs510769	TT	56	0.667	167	0.749	2.744	0.0976
	TC	24	0.286	53	0.237
	CC	4	0.048	4	0.018
rs696522	AA	64	0.762	215	0.907	11.097	0.0009*
	AG	19	0.226	21	0.089
	GG	1	0.012	1	0.004
rs1381376	CC	70	0.769	221	0.913	13.409	0.0003*
	CT	20	0.220	21	0.087
	TT	1	0.011	0	0.000
rs3778151	GG	66	0.733	215	0.896	14.655	0.0001*
	GA	23	0.256	25	0.104
	AA	1	0.011	0	0.000
rs2075572	GG	50	0.556	149	0.642	1.574	0.2096
	GC	33	0.367	82	0.353
	CC	7	0.078	11	0.047
rs533586	TT	68	0.840	203	0.868	0.761	0.3830
	TC	12	0.148	31	0.132
	CC	1	0.012	0	0.000
rs550014	TT	78	0.857	203	0.832	0.093	0.7602
	TC	12	0.132	41	0.168
	CC	1	0.011	0	0.000
rs658156	GG	65	0.714	192	0.787	2.041	0.1531
	GA	24	0.264	52	0.213
	AA	1	0.011	0	0.000

ISSN: 2730-6844