Gene | Polymorphism | Allele (MA) | Population MAF (95% CI) | White/ Caucasian MAF (95% CI) | White Hispanic MAF (95% CI) | Black African American MAF (95% CI) | Asian Hmong MAF (95% CI) | American Indian MAF (95% CI) | P value |
---|---|---|---|---|---|---|---|---|---|
LEPR | rs1137101 | G(A) | 0.459 (0.454-0.464) | 0.544 (0.539-0.549) | 0.493 (0.445-0.541) | 0.410 (0.314-0.506) | 0.330 (0.263-0.397) | 0.479 (0.425-0.533) | <0.0001 |
RNASEL | rs486907 | G(A) | 0.375 (0.370-0.380) | 0.379 (0.374-0.384) | 0.214 (0.174-0.254) | 0.100 (0.041-0.159) | 0.308 (0.242-0.374) | 0.284 (0.236-0.332) | <0.0001 |
APOB | rs1042031 | G(A) | 0.180 (0.176-0.184) | 0.18 (0.176-0.184) | 0.167 (0.131-0.203) | 0.220 (0.139-0.301) | 0.063 (0.028-0.098) | 0.182 (0.141-0.223) | 0.0023 |
CTLA4 | rs231775 | A(G) | 0.388 (0.383-0.393) | 0.386 (0.381-0.391) | 0.480 (0.432-0.528) | 0.370 (0.275-0.465) | 0.479 (0.408-0.550) | 0.413 (0.360-0.466) | <0.0001 |
AGTR1 | rs5186 | A(C) | 0.298 (0.293-0.303) | 0.299 (0.294-0.304) | 0.306 (0.262-0.350) | 0.110 (0.049-0.171) | 0.106 (0.062-0.150) | 0.287 (0.238-0.336) | <0.0001 |
DRD3 | rs6280 | T(C) | 0.315 (0.310-0.320) | 0.311 (0.306-0.316) | 0.480 (0.432-0.528) | 0.240 (0.156-0.324) | 0.297 (0.232-0.362) | 0.359 (0.308-0.410) | <0.0001 |
FABP2 | rs1799883 | G(A) | 0.262 (0.258-0.266) | 0.261 (0.257-0.265) | 0.293 (0.249-0.337) | 0.240 (0.156-0.324) | 0.250 (0.188-0.312) | 0.295 (0.246-0.344) | 0.3968 |
ADD1 | rs4961 | G(T) | 0.192 (0.188-0.196) | 0.191 (0.187-0.195) | 0.209 (0.170-0.248) | 0.100 (0.041-0.159) | 0.346 (0.278-0.414) | 0.165 (0.125-0.205) | <0.0001 |
ADRB2 | rs1042714 | C(G) | 0.428 (0.423-0.433) | 0.433 (0.428-0.438) | 0.214 (0.174-0.254) | 0.250 (0.165-0.335) | 0.170 (0.116-0.224) | 0.404 (0.351-0.457) | <0.0001 |
FGFR4 | rs351855 | C(T) | 0.305 (0.300-0.310) | 0.303 (0.298-0.308) | 0.430 (0.382-0.478) | 0.170 (0.096-0.244) | 0.436 (0.365-0.507) | 0.314 (0.264-0.364) | <0.0001 |
EDN1 | rs5370 | G(T) | 0.213 (0.209-0.217) | 0.214 (0.210-0.218) | 0.182 (0.145-0.219) | 0.180 (0.105-0.255) | 0.255 (0.193-0.317) | 0.165 (0.125-0.205) | 0.0835 |
HTR1B | rs6296 | G(C) | 0.270 (0.266-0.274) | 0.268 (0.264 -0.272) | 0.391 (0.344-0.438) | 0.220 (0.139-0.301) | 0.367 (0.298-0.436) | 0.320 (0.270-0.370) | <0.0001 |
EGFR | rs2227983 | G(A) | 0.255 (0.251-0.259) | 0.253 (0.249-0.257) | 0.313 (0.268-0.358) | 0.090 (0.034-0.146) | 0.527 (0.456-0.598) | 0.275 (0.227-0.323) | <0.0001 |
CFTR | rs213950 | G(A) | 0.428 (0.423-0.433) | 0.426 (0.421-0.431) | 0.512 (0.464-0.560) | 0.760 (0.676-0.844) | 0.484 (0.413-0.555) | 0.389 (0.337-0.441) | <0.0001 |
PON2 | rs7493 | C(G) | 0.244 (0.240-0.248) | 0.244 (0.240-0.248) | 0.231 (0.190-0.272) | 0.350 (0.257-0.443) | 0.245 (0.184-0.306) | 0.207 (0.164-0.250) | 0.2519 |
LPL | rs328 | C(G) | 0.098 (0.095-0.101) | 0.098 (0.095-0.101) | 0.083 (0.056-0.110) | 0.080 (0.027-0.133) | 0.080 (0.041-0.119) | 0.108 (0.075-0.141) | 0.9200 |
9p21 | rs2383206 | A(G) | 0.500 (0.495-0.505) | 0.499 (0.494-0.504) | 0.551 (0.503-0.599) | 0.550 (0.452-0.648) | 0.505 (0.434-0.576) | 0.547 (0.494-0.600) | 0.2803 |
RET | rs1800861 | A(C) | 0.233 (0.229-0.237) | 0.232 (0.228-0.236) | 0.218 (0.178-0.258) | 0.130 (0.064-0.196) | 0.452 (0.381-0.523) | 0.219 (0.175-0.263) | <0.0001 |
ADRB1 | rs1801253 | C(G) | 0.270 (0.266-0.274) | 0.271 (0.267-0.275) | 0.163 (0.127-0.199) | 0.500 (0.402-0.598) | 0.229 (0.169-0.289) | 0.222 (0.177-0.267) | <0.0001 |
PLAU | rs2227564 | C(T) | 0.247 (0.243-0.251) | 0.247 (0.243-0.251) | 0.250 (0.208-0.292) | 0.100 (0.041-0.159) | 0.299 (0.234-0.364) | 0.246 (0.200-0.292) | 0.354 |
MMP1 | rs1799750 | -(G) | 0.471 (0.466-0.476) | 0.469 (0.464-0.474) | 0.638 (0.592-0.684) | 0.460 (0.362-0.558) | 0.565 (0.494-0.636) | 0.494 (0.440-0.548) | <0.0001 |
VWF | rs1063856 | A(G) | 0.359 (0.354-0.364) | 0.361 (0.356-0.366) | 0.250 (0.208-0.292) | 0.490 (0.392-0.588) | 0.170 (0.116-0.224) | 0.290 (0.241-0.339) | <0.0001 |
HTR2A | rs6313 | C(T) | 0.406 (0.401-0.411) | 0.406 (0.401-0.411) | 0.369 (0.322-0.416) | 0.350 (0.257-0.443) | 0.450 (0.379-0.521) | 0.392 (0.340-0.444) | 0.3286 |
MTHFD1 | rs2236225 | C(T) | 0.448 (0.443-0.453) | 0.447 (0.442-0.452) | 0.578 (0.530-0.626) | 0.240 (0.156-0.324) | 0.293 (0.228-0.358) | 0.476 (0.422-0.530) | <0.0001 |
LIPC | rs1800588 | C(T) | 0.218 (0.214-0.222) | 0.214 (0.210-0.218) | 0.480 (0.432-0.528) | 0.430 (0.333-0.527) | 0.346 (0.278-0.414) | 0.254 (0.207-0.301) | <0.0001 |
MMP2 | rs243865 | C(T) | 0.246 (0.242-0.250) | 0.247 (0.243-0.251) | 0.218 (0.178-0.258) | 0.100 (0.041-0.159) | 0.112 (0.067-0.157) | 0.257 (0.210-0.304) | <0.0001 |
CYBA | rs4673 | C(T) | 0.339 (0.334-0.344) | 0.341 (0.336-0.346) | 0.209 (0.170-0.248) | 0.370 (0.275-0.465) | 0.213 (0.154-0.272) | 0.371 (0.319-0.423) | <0.0001 |
CETP | rs708272 | C(T) | 0.421 (0.416-0.426) | 0.422 (0.417-0.427) | 0.432 (0.384-0.480) | 0.306 (0.216-0.396) | 0.398 (0.328-0.468) | 0.428 (0.375-0.481) | 0.0924 |
ELAC2 | rs4792311 | G(A) | 0.303 (0.298-0.308) | 0.304 (0.299-0.309) | 0.262 (0.220-0.304) | 0.280 (0.192-0.368) | 0.165 (0.112-0.218) | 0.317 (0.267-0.367) | <0.0001 |
ENOSF1/TYMS | rs16430 | +(-) | 0.299 (0.294-0.304) | 0.297 (0.292-0.302) | 0.347 (0.301-0.393) | 0.470 (0.372-0.568) | 0.585 (0.515-0.655) | 0.293 (0.244-0.342) | <0.0001 |
FUT2 | rs601338 | G(A) | Â | 0.456 (0.451-0.461) | 0.267 (0.224-0.310) | 0.500 (0.402-0.598) | 0.133 (0.084-0.182) | 0.410 (0.357-0.463) | <0.0001 |
LDLR | rs688 | C(T) | 0.422 (0.417-0.427) | 0.423 (0.418-0.428) | 0.425 (0.377-0.473) | 0.150 (0.080-0.220) | 0.335 (0.268-0.402) | 0.467 (0.413-0.521) | <0.0001 |
GNAS | rs7121 | C(T) | 0.480 (0.475-0.485) | 0.477 (0.472-0.482) | 0.575 (0.527-0.623) | 0.700 (0.610-0.790) | 0.606 (0.536-0.676) | 0.545 (0.492-0.598) | <0.0001 |
CBS | rs234706 | G(A) | 0.345 (0.340-0.350) | 0.348 (0.343-0.353) | 0.233 (0.192-0.274) | 0.220 (0.139-0.301) | 0.118 (0.072-0.164) | 0.335 (0.284-0.386) | <0.0001 |
IL1B | rs16944 | G(A) | 0.334 (0.329-0.339) | 0.329 (0.324-0.334) | 0.566 (0.518-0.614) | 0.550 (0.452-0.648) | 0.500 (0.429-0.571) | 0.437 (0.384-0.490) | <0.0001 |
NOS3 | rs1799983 | G(T) | 0.306 (0.301-0.311) | 0.308 (0.303-0.313) | 0.228 (0.187-0.269) | 0.130 (0.064-0.196) | 0.149 (0.098-0.200) | 0.263 (0.216-0.310) | <0.0001 |
TGFB1 | rs1800469 | C(T) | 0.308 (0.303-0.313) | 0.306 (0.301-0.311) | 0.468 (0.420-0.516) | 0.250 (0.165-0.335) | 0.410 (0.340-0.480) | 0.287 (0.238-0.336) | <0.0001 |
TNFa | rs1800629 | G(A) | 0.170 (0.166-0.174) | 0.171 (0.167-0.175) | 0.083 (0.056-0.110) | 0.160 (0.088-0.232) | 0.080 (0.041-0.119) | 0.132 (0.096-0.168) | <0.0001 |
IL6 | rs1800795 | G(C) | 0.434 (0.429-0.439) | 0.440 (0.435-0.445) | 0.199 (0.160-0.238) | 0.160 (0.088-0.232) | 0.085 (0.045-0.125) | 0.326 (0.276-0.376) | <0.0001 |
IL6 | rs1800796 | G(C) | 0.057 (0.055-0.059) | 0.052 (0.050-0.054) | 0.260 (0.218-0.302) | 0.110 (0.049-0.171) | 0.479 (0.408-0.550) | 0.111 (0.077-0.145) | <0.0001 |
IL10 | rs1800872 | C(A) | 0.244 (0.240-0.248) | 0.240 (0.236-0.244) | 0.362 (0.316-0.408) | 0.350 (0.257-0.443) | 0.553 (0.482-0.624) | 0.269 (0.221-0.317) | <0.0001 |
MTHFR | rs1801133 | C(T) | 0.327 (0.322-0.332) | 0.327 (0.322-0.332) | 0.485 (0.437-0.533) | 0.100 (0.041-0.159) | 0.229 (0.169-0.289) | 0.344 (0.293-0.395) | <0.0001 |
LPL | rs268 | A(G) | 0.020 (0.019-0.021) | 0.020 (0.019-0.021) | 0.001 (0.000-0.004) | 0 | 0 | 0.015 (0.002-0.028) | NA |
ACE | rs4291 | A(T) | 0.377 (0.372-0.382) | 0.389 (0.384-0.394) | 0.415 (0.367-0.463) | 0.347 (0.254-0.440) | 0.316 (0.250-0.382) | 0.377 (0.325-0.429) | 0.2086 |
ACE | rs4343 | G(A) | 0.481 (0.476-0.486) | 0.479 (0.474-0.484) | 0.556 (0.508-0.604) | 0.710 (0.621-0.799) | 0.580 (0.509-0.651) | 0.488 (0.434-0.542) | <0.0001 |
APOE | rs429358 | T(C) | 0.144 (0.141-0.147) | 0.145 (0.141-0.149) | 0.100 (0.071-0.129) | 0.220 (0.139-0.301) | 0.085 (0.045-0.125) | 0.123 (0.088-0.158) | 0.0108 |
APOE | rs7412 | C(T) | 0.083 (0.080-0.086) | 0.083 (0.080-0.086) | 0.030 (0.014-0.046) | 0.140 (0.072-0.208) | 0.060 (0.026-0.094) | 0.084 (0.054-0.114) | 0.0056 |
COMT | rs4680 | A(G) | 0.469 (0.464-0.474) | 0.466 (0.461-0.471) | 0.570 (0.522-0.618) | 0.690 (0.599-0.781) | 0.654 (0.586-0.722) | 0.461 (0.408-0.514) | <0.0001 |
VDR | rs7975232 | A(C) | 0.485 (0.480-0.490) | 0.483 (0.478-0.488) | 0.573 (0.525-0.621) | 0.410 (0.314-0.506) | 0.633 (0.564-0.702) | 0.500 (0.446-0.554) | <0.0001 |
VDR | rs731236 | T(C) | 0.384 (0.379-0.389) | 0.387 (0.382-0.392) | 0.245 (0.203-0.287) | 0.320 (0.229-0.411) | 0.165 (0.112-0.218) | 0.359 (0.308-0.410) | <0.0001 |
VDR | rs1544410 | G(A) | 0.389 (0.384-0.394) | 0.392 (0.387-0.397) | 0.243 (0.202-0.284) | 0.310 (0.219-0.401) | 0.223 (0.163-0.283) | 0.344 (0.293-0.395) | <0.0001 |