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Table 1 The distribution of the GST genotypes in Black and Mixed Ancestry in South Africans

From: The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer

Genotypes Black African subjects Mixed Ancestry subjects Analysis of subjects combined
  Patients
N (%)
Controls
N (%)
Patients
N (%)
Controls
N (%)
OR1(95%CI) p - value OR2(95%CI) p-value
GSTT1a
*1 57 (40) 109 (59) 68 (68) 69 (73) 1.00 1.00
*0 (rs71748309) 84 (60) 77 (41) 29 (29) 25 (27) 1.55 (1.09-2.21) 0.014 1.71 (1.18-2.46) 0.004
GSTP1 313 A/G (Ile105Val) (rs1695)
313A/A 56 (40) 76 (41) 34 (34) 30 (32) 1.00  
313A/G 59 (42) 83 (45) 52 (52) 51 (54) 0.96 (0.66-1.40) 0.846 1.01 (0.68-1.48) 0.973
313G/G 26 (18) 27 (14) 11 (11) 13 (14) 1.08 (0.64-1.82) 0.786 1.21 (0.71-2.07) 0.490
Test for deviation from Hardy-Weinberg Equilibrium
χ 2 2.139 0.360 1.874 1.407   
p 0.144 0.549 0.177 0.236   
313A freq 0.61+0.03 0.63+0.02 0.62+0.03 0.59+0.03   
313G freq 0.39+0.03 0.37+0.02 0.38+0.03 0.41+0.03   
GSTP1 341 C/T (Ala114Val) (rs1138272)
341C/C 85 (60) 163 (88) 65 (65) 89 (95) 1.00 1.00
341C/T 49 (35) 21 (11) 27 (27) 5 (5) 4.98 (3.05-8.11) 0.001 5.05 (3.06-8.32) 0.001
341T/T 7 (5) 2 (1) 5 (5) 0 (0) 10.9 (2.43-49.1) 0.002 9.58 (2.08-44.0) 0.004
Test for deviation from Hardy-Weinberg Equilibrium
χ 2 0 1.397 0.876 0.137   
p 0.986 0.237 0.349 0.712   
341C freq 0.78+0.02 0.93+0.01 0.81+0.03 0.97+0.01   
341T freq 0.22+0.02 0.07+0.01 0.19+0.03 0.03+0.01   
  1. OR1, odds ratio not adjusted for confounders; OR2, odds ratio adjusted for the following confounding variables, age, sex, race, tobacco smoking, alcohol consumption and use of wood or charcoal; . a *1 signifies carrier of gene (either homozygous or heterozygous carrier), *0 signifies homozygous gene deletion