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Table 7 Top SNP in each gene identified from the three-stage analyses of Uric acid levels in FHS SHARe project.

From: A three-stage approach for genome-wide association studies with family data for quantitative traits

SNP

Chr

Position

Gene

MAF

LM pval

LME pval

FBAT pval

Direction

Three-stage pval

Three-stage pval for top SNPs

rs1165205

6

25978521

SLC17A3

0.46

3.2E-11

5.6E-10

7.1E-03

---

1.0E+00

2.1E-02

rs2231142

4

89271347

ABCG2

0.11

2.4E-23

9.0E-20

5.6E-11

+++

8.3E-09

1.7E-10

rs16890979

4

9531265

SLC2A9

0.23

3.4E-88

1.6E-76

8.3E-23

---

1.2E-20

2.5E-22

  1. 1) Direction: the three signs are the direction of changes in multivariable adjusted uric acid per minor allele in the LM, LME and FBAT analyses, respectively.
  2. 2) Three-stage pval: Three-stage p-values adjusting for the multiple testing of all SNPs with p-value < 5 × 10-8 in the second stage.
  3. 3) Three-stage pval for top SNPs: Three-stage p-values adjusting for the multiple testing of only the top SNP in each gene among all SNPs with p-value < 5 × 10-8 in the second stage.
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BMC Genomic Data

ISSN: 2730-6844

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