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Table 2 Genotypic frequencies and associations of SNPs in IL10, IL10RA/B, TGFB1, and SLC11A1 with MAP-infection status.

From: Polymorphisms in the gene encoding bovine interleukin-10 receptor alpha are associated with Mycobacterium avium ssp. paratuberculosis infection status

    MAP infection status   
    Negative Positive   
Gene SNP Genotype # (%) # (%) Effect ± SE OR (CI)
IL10 -285T > C n 208 178 α: -0.29 ± 0.28 0.75 (0.43-1.29)
   TT 163 (78.4) 136 (76.4) δ: 0.45 ± 0.37 1.58 (0.76-3.29)
   CT 34 (16.3) 37 (20.8)   
   CC 11 (5.3) 5 (2.8)   
IL10RA 633C > A n 238 193 α: -0.62 ± 0.32* 0.54 (0.29-1.00)
   CC 10 (4.2) 7 (3.6) δ: -0.54 ± 0.36 0.58 (0.29-1.18)
   CA 72 (30.3) 54 (28)   
   AA 156 (65.5) 132 (68.4)   
  984G > A n 235 183 α: -0.67 ± 0.22** 0.51 (0.34-0.78)
   AA 56 (23.8) 18 (9.8) δ: 0.82 ± 0.25** 2.27 (1.40-3.67)
   AG 111 (47.2) 109 (59.6)   
   GG 68 (28.9) 56 (30.6)   
  1185C > T n 240 198 rm rm
   TT 18 (7.5) 5 (2.5)   
   TC 93 (38.8) 75 (37.9)   
   CC 129 (53.8) 118 (59.6)   
IL10RB 503C > T n 216 182 α: 0.27 ± 0.17 1.31 (0.95-1.81)
   CC 36 (16.7) 22 (12.1) δ: 0.07 ± 0.22 1.08 (0.69-1.67)
   TC 103 (47.7) 89 (48.9)   
   TT 77 (35.6) 71 (39)   
TGFB1 258C > T n 237 201 α: 0.08 ± 0.16 1.08 (0.80-1.47)
   CC 98 (41.4) 74 (36.8) δ: 0.04 ± 0.22 1.04 (0.68-1.58)
   CT 106 (44.7) 97 (48.3)   
   TT 33 (13.9) 30 (14.9)   
SLC11A1 1066C > G n 219 176 α: -0.27 ± 0.37 0.77 (0.37-1.58)
   CC 142 (64.8) 106 (60.2) δ: 0.45 ± 0.41 1.57 (0.70-3.50)
   CG 71 (32.4) 67 (38.1)   
   GG 6 (2.7) 3 (1.7)   
  1. # (%), genotypic count (frequency); Effect ± SE, additive (α) or dominance (δ) effect ± standard error; OR (95% CI), odds ratio (95% confidence interval); rm, removed due to strong multi-collinearity.
  2. * Comparison-wise significance at 5% from logistic regression.
  3. ** Experimental-wise significance at 5% from logistic regression and Bonferroni's procedure for multiple testing correction.