Comparison of Little ROCK and ROCK1 genes. (A) Cartoon demonstrates location of Little ROCK and ROCK1 on chromosome 18 and their exon gene structures. (B) The location of the Little ROCK coding sequence relative to ROCK1 is shown. ROCK1 includes a kinase domain and a Rho binding domain (RBD). Little ROCK and ROCK1 share pleckstrin homology (PH) and cysteine rich (CRD) domains. The amino acid sequence alignment and location of variants reported in dbSNP are shown.