TY - JOUR AU - Nehrenberg, Derrick L. AU - Wang, Shiliang AU - Buus, Ryan J. AU - Perkins, James AU - de Villena, Fernando Pardo-Manuel AU - Pomp, Daniel PY - 2010 DA - 2010/12/31 TI - Genomic mapping of social behavior traits in a F2 cross derived from mice selectively bred for high aggression JO - BMC Genetics SP - 113 VL - 11 IS - 1 AB - Rapid response to selection was previously observed in mice selected for high levels of inter-male aggression based on number of attacks displayed in a novel social interaction test after isolation housing. Attack levels in this high aggression line (NC900) increased significantly within just four generations of selective breeding, suggesting the presence of a locus with large effect. We conducted an experiment using a small (n ≈ 100) F2 cross between the ICR-derived, non-inbred NC900 strain and the low aggression inbred strain C57BL/6J, genotyped for 154 fully informative SNPs, to determine if a locus with large effect controls the high-aggression selection trait. A second goal was to use high density SNP genotyping (n = 549,000) in the parental strains to characterize residual patterns of heterozygosity within NC900, and evaluate regions that are identical by descent (IBD) between NC900 and C57BL/6J, to determine what impacts these may have on accuracy and resolution of quantitative trait locus (QTL) mapping in the F2 cross. SN - 1471-2156 UR - https://doi.org/10.1186/1471-2156-11-113 DO - 10.1186/1471-2156-11-113 ID - Nehrenberg2010 ER -