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Table 3 Associations between SNP alleles with minor allele frequencies and quantitative measures of the hair colours (L*a*b* values) with P < 0.05 in 107 Scots from Edinburgh.

From: Genetic determinants of hair and eye colours in the Scottish and Danish populations

Gene Chr. Positiona SNP Min.
allele 		MAFb L*
p-value 		L*
R2 		a*
p-value 		a*
R2 		b*
p-value 		b*
R2 		Hair colour
HPS3 3 Int 1.1 rs4681169 A 0.30    0.046 0.039    Dark
   Int 1.2 rs16861514 T 0.15    0.043 0.039    Dark
   Int 6 rs16861552 C 0.33    0.021 0.054    Dark
   Int 8 rs6785780 T 0.41    0.003 0.079    Red/Light
   Int 13 rs7636389 A 0.07    0.026 0.049    Red/Light
DTNBP1 6 Exon 10
(S272P) 		rs17470454 A 0.05 0.011 0.060    0.011 0.044 Light
TYRP1 9 Int 6 rs17346161 T 0.06    0.046 0.037    Red/Light
ERCC6 10 Int 5 rs1018603 C 0.11 0.041 0.041    0.041 0.038 Dark
   Int 9 rs4253162 A 0.07 0.011 0.058    0.011 0.060 Dark
KITLG 12 Int 1.1 rs1492354 A 0.07    0.0009d 0.119    Red/Light
   Int 1.2 rs1907702 G 0.20    0.018 0.05    Red/Light
   Int 1.3 rs10777129 A 0.08    0.007 0.06 0.043 0.080 Red/Light
OCA2 15 Int 1.1 rs7495174 G 0.05 0.02 0.051    0.024 0.040 Dark
   Int 1.2 rs7174027 A 0.06 0.005 0.075    0.005 0.060 Dark
   Int 2.1 rs12442147 C 0.11 0.03 0.041 0.010 0.066 0.03 0.065 Dark
   Int 2.2 rs12324648 A 0.07    0.019 0.057    Dark
   Int 2.3 rs1470608 A 0.10    0.012 0.063    Dark
   Int 4 rs3794604 A 0.08    0.031 0.042    Dark
   Int 5 rs749846 A 0.11    0.025 0.054    Dark
   Int 19 rs1375166 A 0.20    0.046 0.039    Dark
   Int 23.1 rs2311470 C 0.50    0.005 0.073    Dark
   Int 23.2 rs11858340 A 0.44    0.016 0.053    Red/Light
   Int 23.3 rs6497235 A 0.50 0.03 0.050 0.006 0.069 0.03 0.063 Light
   Int 23.4 rs11074306 A 0.41    0.024 0.048    Dark
   Int 23.5 rs6497233 T 0.41 0.02 0.053 0.0004e 0.116 0.021 0.098 Light
   Int 23.6 rs17674017 G 0.42    0.005 0.073    Red/Light
   Int 23.7 rs1498509 C 0.49    0.010 0.060    Dark
   Int 23.8 rs11631195 A 0.37 0.004 0.079 0.0002d 0.126 0.0037c 0.130 Light
   Int 23.9 rs3947367 G 0.29 0.012 0.059    0.012 0.039 Light
   Int 23.10 rs11637518 G 0.35 0.014 0.051 0.009 0.064 0.014 0.078 Light
   Int 23.11 rs989869 C 0.38 0.008 0.063    0.0077 0.053 Dark
   Int 23.12 rs1603784 A 0.23 0.007 0.063    0.0069 0.041 Dark
MYO05 15 Int 1.1 rs1615028 C 0.17 0.046 0.037      Light
   Int 1.2 rs1724593 G 0.15 0.012 0.059    0.012 0.066 Light
   Int 1.3 rs7176061 C 0.48 0.046 0.041      Dark
   Int 2 rs1724625 T 0.30 0.036 0.044      Light
   Int 5 rs1724630 G 0.21 0.049 0.039    0.049 0.040 Light
   Int 9 rs1632403 T 0.08 0.042 0.039    0.042 0.049 Light
MC1R 16 Exon R None 0.21    2.00 × 10-6c 0.317 0.047c 0.156 Red
   Exon r None 0.23    0.005 0.07    Dark/Light
PRKAR1A 17 Int 2 rs2952275 T 0.36 0.047 0.036      Light
   5' UTR rs8080306 C 0.27 0.021 0.047      Light
GNAS 20 Int 3 rs2295583 T 0.28 0.03 0.43      Light
   Int 5 rs3730168 A 0.41 0.015 0.052      Dark
   Int 6 rs919197 T 0.43 0.006 0.07    0.0062 0.059 Light
HPS4 22 Int 2 rs9613187 T 0.11 0.012 0.059    0.012 0.037 Light
   Int 5 rs17401652 T 0.10    0.028 0.047    Red/Light
  1. a: Intron (Int), Exon or Untranslated region (UTR) position in the gene
  2. b: Minor allele frequency (MAF)
  3. c: Significant using Bonferroni correction. Other L*, a* and b* values were corrected using empirical permutations
  4. d: Significant using False Discovery Rate correction
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BMC Genomic Data

ISSN: 2730-6844

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