TY - JOUR AU - Uh, Hae-Won AU - Houwing-Duistermaat, Jeanine J. AU - Putter, Hein AU - van Houwelingen, Hans C. PY - 2009 DA - 2009/09/14 TI - Assessment of global phase uncertainty in case-control studies JO - BMC Genetics SP - 54 VL - 10 IS - 1 AB - In haplotype-based candidate gene studies a problem is that the genotype data are unphased, which results in haplotype ambiguity. The measure [1] quantifies haplotype predictability from genotype data. It is computed for each individual haplotype, and for a measure of global relative efficiency a minimum value is suggested. Alternatively, we developed methods directly based on the information content of haplotype frequency estimates to obtain global relative efficiency measures: and based on A- and D-optimality, respectively. All three methods are designed for single populations; they can be applied in cases only, controls only or the whole data. Therefore they are not necessarily optimal for haplotype testing in case-control studies. SN - 1471-2156 UR - https://doi.org/10.1186/1471-2156-10-54 DO - 10.1186/1471-2156-10-54 ID - Uh2009 ER -