Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites

Table 1 Mean, standard deviation (SD), and range for MAF and F_ST by SNP function

SNP function	Number of SNPs	Puerto Rican			non-Hispanic white
		Mean (SD) MAF	Mean (SD) F_ST	Range F_ST	Mean (SD) MAF	Mean (SD) F_ST	Range F_ST
3'UTR	5	0.20 (0.10)	0.022 (0.050)	0.112	0.19 (0.14)	0.050 (0.067)	0.141
Intron	37	0.31 (0.13)	0.019 (0.029)	0.131	0.29 (0.13)	0.019 (0.032)	0.134
Non-Synonymous	27	0.15 (0.10)¹	0.041 (0.061)	0.255	0.16 (0.12)²	0.033 (0.053)	0.166
Promoter	22	0.30 (0.15)	0.022 (0.061)	0.290	0.27 (0.15)	0.033 (0.058)	0.250
Synonymous	8	0.28 (0.14)	0.036 (0.061)	0.177	0.32 (0.18)	0.013 (0.029)	0.085

¹ Significantly different from Puerto Rican intron (p < 0.001), promoter (p = 0.001), synonymous SNPs (p = 0.015)
² Significantly different from NHW intron (p < 0.001), promoter (p = 0.014), synonymous SNPs (p = 0.027)

ISSN: 2730-6844