Table 6 Allele-wise analyses for prostate cancer risk in the multiethnic studies
| Â | Â | Â | rs1447295 | Â | Â | Â | Â |
|---|---|---|---|---|---|---|---|
| Â | Â | Â | A allele frequency | Â | Â | Â | Â |
Author (Year) | N cases/N controls | Study population | Cases | Controls | OR | 95% CI | p value |
Amundadottir, et al. (2006) | 1291/997 | Iceland | 0.17 | 0.11 | 1.72 | — | 1.7 × 10-9 |
|  | 1435/779 | Sweden | 0.16 | 0.13 | 1.29 | — | 4.5 × 10-3 |
|  | 458/247 | European Americans | 0.13 | 0.08 | 1.66 | — | 6.7 × 10-3 |
|  | 246/352 | African Americans | 0.34 | 0.31 | 1.15 | — | 0.29 |
Freedman, et al. (2006) | 70/68 | Native Hawaiians | 0.37 | 0.16 | 3.02 | 1.66 – 5.50 | 1.5 × 10-4 |
|  | 449/465 | Japanese Americans | 0.24 | 0.17 | 1.48 | 1.18 – 1.86 | 3.4 × 10-4 |
|  | 640/567 | Latino Americans | 0.14 | 0.10 | 1.48 | 1.14 – 1.91 | 1.4 × 10-3 |
|  | 455/447 | European Americans | 0.13 | 0.10 | 1.35 | 1.01 – 1.80 | 0.02 |
|  | 989/804 | African Americans | — | — | 1.05 | 0.95 – 1.16 | 0.15 |
Wang, et al. (2007) | 491/545 | Caucasians | 0.12 | 0.10 | 1.16 | 0.85 – 1.58 | 0.25 |
|  | 435/545 | Caucasians* | 0.17 | 0.10 | 1.93 | 1.37 – 2.72 | 4.0 × 10-3 |
Gudmundsson, et al. (2007) | 1453/3064 | Iceland | 0.17 | 0.10 | 1.71 | 1.49 – 1.95 | 1.6 × 10-14 |
|  | 385/892 | Spain | 0.10 | 0.07 | 1.44 | 1.07 – 1.94 | 1.7 × 10-2 |
|  | 367/1302 | The Netherlands | 0.14 | 0.11 | 1.39 | 1.09 – 1.78 | 9.0 × 10-3 |
|  | 373/372 | African Americans | 0.32 | 0.31 | 1.01 | 0.81 – 1.25 | 0.96 |
Haiman, et al. (2007) | 1614/837 | African Americans | — | — | — | — | — |
|  | 722/728 | Japanese Americans | — | — | — | — | — |
|  | 111/112 | Native Hawaiians | — | — | — | — | — |
|  | 637/633 | Latino Americans | — | — | — | — | — |
|  | 1182/942 | European Americans | — | — | — | — | — |
Robbins, et al. (2007) | 490/567 | African Americans | 0.34 | 0.31 | 1.40 | 0.70 – 1.30 | 0.13 |
Present study (2009) | 391/323 | Native Japanese | 0.25 | 0.19 | 1.34 | 1.01 – 1.79 | 0.04 |
| Â | Â | Â | rs6983267 | Â | Â | Â | Â |
| Â | Â | Â | G allele frequency | Â | Â | Â | Â |
Author (Year) | N cases/N controls | Study population | Cases | Controls | OR | 95% CI | p value |
Amundadottir, et al. (2006) | 1291/997 | Iceland | — | — | — | — | — |
|  | 1435/779 | Sweden | — | — | — | — | — |
|  | 458/247 | European Americans | — | — | — | — | — |
|  | 246/352 | African Americans | — | — | — | — | — |
Freedman, et al. (2006) | 70/68 | Native Hawaiians | — | — | — | — | — |
|  | 449/465 | Japanese Americans | — | — | — | — | — |
|  | 640/567 | Latino Americans | — | — | — | — | — |
|  | 455/447 | European Americans | — | — | — | — | — |
|  | 989/804 | African Americans | — | — | — | — | — |
Wang, et al. (2007) | 491/545 | Caucasians | — | — | — | — | — |
|  | 435/545 | Caucasians* | — | — | — | — | — |
Gudmundsson, et al. (2007) | 1453/3064 | Iceland | — | — | — | — | — |
|  | 385/892 | Spain | — | — | — | — | — |
|  | 367/1302 | The Netherlands | — | — | — | — | — |
|  | 373/372 | African Americans | — | — | — | — | — |
Haiman, et al. (2007) | 1614/837 | African Americans | 0.90†| 0.84 | 1.43 | 1.17 – 1.75 | — |
|  | 722/728 | Japanese Americans | 0.37†| 0.32 | 1.22 | 1.05 – 1.42 | — |
|  | 111/112 | Native Hawaiians | 0.36†| 0.28 | 1.29 | 0.88 – 1.89 | — |
|  | 637/633 | Latino Americans | 0.63†| 0.62 | 1.05 | 0.89 – 1.24 | — |
|  | 1182/942 | European Americans | 0.54†| 0.51 | 1.13 | 0.99 – 1.28 | — |
Robbins, et al. (2007) | 490/567 | African Americans | 0.08 | 0.11 | 1.40 | 0.90 – 2.40 | 0.17 |
Present study (2009) | 391/323 | Native Japanese | 0.38 | 0.31 | 1.27 | 0.99 – 1.62 | 0.06 |