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Table 4 Prostate cancer susceptibility stratified by Gleason score, T-stage, and serum PSA levels at diagnosis (control vs. SPCa)

From: Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men

Genotype

Gleason score ≤ 7

(N = 241)

Gleason score ≥ 8

(N = 150)

 

OR*

95% CI

p value

OR*

95% CI

p value

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CC

1.0

reference

 

1.0

reference

 

CA

1.62

1.08 – 2.42

0.02

1.48

0.94 – 2.34

0.09

AA

1.09

0.46 – 2.56

0.84

1.63

0.66 – 3.92

0.29

CA + AA

1.53

1.04 – 2.25

0.03

1.50

0.97 – 2.32

0.07

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TT

1.0

reference

 

1.0

reference

 

TG

0.93

0.62 – 1.39

0.73

0.90

0.57 – 1.42

0.66

GG

1.84

0.96 – 3.55

0.07

2.41

1.20 – 4.86

0.01

TG + GG

1.05

0.72 – 1.55

0.79

1.10

0.72 – 1.69

0.67

Genotype

 

T1 or T2

(N = 167)

  

T3 or T4

(N = 224)

 
 

OR*

95% CI

p value

OR*

95% CI

p value

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CC

1.0

reference

 

1.0

reference

 

CA

1.39

0.88 – 2.17

0.15

1.70

1.14 – 2.56

0.01

AA

1.34

0.53 – 3.29

0.53

1.28

0.55 – 2.95

0.57

CA + AA

1.38

0.90 – 2.11

0.14

1.64

1.11 – 2.41

0.01

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TT

1.0

reference

 

1.0

reference

 

TG

0.96

0.61 – 1.51

0.87

0.91

0.61 – 1.36

0.65

GG

2.68

1.37 – 5.30

4.0 × 10-3

1.69

0.87 – 3.31

0.12

TG + GG

1.19

0.78 – 1.83

0.42

1.02

0.69 – 1.49

0.93

Genotype

 

PSA < 20 ng/mL

(N = 208)

  

PSA ≥ 20 ng/mL

(N = 183)

 
 

OR*

95% CI

p value

OR*

95% CI

p value

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CC

1.0

reference

 

1.0

reference

 

CA

1.46

0.95 – 2.23

0.08

1.71

1.12 – 2.60

0.01

AA

0.97

0.37 – 2.44

0.95

1.69

0.74 – 3.83

0.21

CA + AA

1.38

0.92 – 2.08

0.12

1.70

1.14 – 2.54

9.0 × 10-3

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TT

1.0

reference

 

1.0

reference

 

TG

0.96

0.63 – 1.47

0.86

0.92

0.60 – 1.40

0.69

GG

1.46

0.72 – 2.96

0.30

2.74

1.45 – 5.24

2.0 × 10-3

TG + GG

1.03

0.69 – 1.55

0.88

1.16

0.78 – 1.73

0.47

Genotype

 

Nonaggressive

(N = 99)

  

Aggressivea

(N = 292)

 
 

OR*

95% CI

p value

OR*

95% CI

p value

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CC

1.0

reference

 

1.0

reference

 

CA

1.69

0.98 – 2.91

0.06

1.54

1.06 – 2.25

0.02

AA

1.39

0.44 – 3.99

0.56

1.28

0.59 – 2.81

0.53

CA + AA

1.64

0.97 – 2.75

0.06

1.50

1.05 – 2.15

0.03

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TT

1.0

reference

 

1.0

reference

 

TG

0.99

0.58 – 1.71

0.97

0.93

0.64 – 1.36

0.72

GG

1.45

0.58 – 3.46

0.42

2.32

1.29 – 4.26

0.01

TG + GG

1.05

0.63 – 1.78

0.85

1.12

0.79 – 1.60

0.52

  1. OR*, Age-adjusted odds ratio.
  2. a Aggressive, Gleason score ≥ 8, and/or T-stage T3 or T4, and/or PSA ≥ 20 ng/mL.