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Table 3 Missense mutations in the ovine TLR4

From: Novel mutations in TLR genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection

  

Wild type frequency

Frequency of mutation in heterozygous state

Frequency of mutation in homozygous state

881G>R

Ser294 [Ser, Asn]

0.84 (12.6%)

0.14 (5.7%)

0.02 (0%)

883A>R

Lys295 [Lys, Glu]

0.84 (12.6%)

0.14 (5.7%)

0.02 (0%)

892T>Y

Trp298 [Trp, Arg]

0.84 (12.6%)

0.14 (5.7%)

0.02 (0%)

934G>A

Val312Met

0.998 (11.4%)

0

0.002 (0%)

955T>C

Ser319Pro

0.998 (11.4%)

0

0.002 (0%)

1029T>K

Asp343 [Glu, Asp]

0.993 (11.4%)

0.007 (0%)

0

1032G>S

Lys344 [Asn, Lys]

0.87 (12.6%)

0.12 (3.5%)

0.012 (0%)

1045A>G

Lys349Glu

0.998 (11.4%)

0

0.002 (0%)

1052G>R

Arg351 [His, Arg]

0.87 (12.3%)

0.12 (5.8%)

0.012 (0%)

1066T>Y

Phe356 [Leu, Phe]

0.36 (14.3%)

0.52 (8.2%)

0.12 (16.4%, 1.64)1

1088A>R

Asp363 [Asp, Gly]

0.84 (12.5%)

0.14 (5.7%)

0.02 (0%)

1091T>Y

Val364 [Val, Ala]

0.84 (12.5%)

0.14 (5.7%)

0.02 (0%)

1097C>S

Thr366 [Thr, Ser]

0.84 (12.5%)

0.14 (5.7%)

0.02 (0%)

1166G>S

Ser389 [Thr, Ser]

0.998 (11.4%)

0.001 (0%)

0

1183G>K

Asp395 [Asp, Tyr]

0.84 (12.5%)

0.14 (6%)

0.002 (0%)

  1. 1 The first value in the parenthesis indicate the percentage of animals infected with MAP that carries given point mutation, the second value (bold-italics) is the Odd's ratio (OR) indicating the possible linkage between the point mutation and increased susceptibility to MAP infection.