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Table 1 Missense mutations in the ovine TLR1

From: Novel mutations in TLR genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection

  

Wild type frequency

Frequency of mutation in heterozygous state

Frequency of mutation in homozygous state

418A>G

Lys140Glu

0.997 (11.4%)

0

0.002 (0%)

431A>T

Asn144Ile

0.997 (11.4%)

0

0.002 (0%)

448A>G

Ser150Gly

0.897 (8.38%)

0

0.10 (43.2%, 9.08)1

508T>C

Ser170Pro

0.997 (11.4%)

0

0.002 (0%)

517G>R

Glu173 [Lys, Glu]

0.897 (8.38%)

0.10(43.2%, 9.08)

0

601A>T

Ile201Phe

0.997 (11.4%)

0

0.002 (0%)

603T>C

Ile201Phe

0.997 (11.4%)

0

0.002 (0%)

658A>G

Val220Met

0.897 (8.38%)

0

0.102 (43.2%, 9.08)

  1. 1 The first value in the parenthesis indicate the percentage of animals infected with MAP that carries given point mutation, the second value (bold-italics) is the Odd's ratio (OR) indicating the possible linkage between the point mutation and increased susceptibility to MAP infection.