From: A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines
Parameter | Chr 4 (117–281) | Chr 4 (281–51) | Chr 11 (Trp53-Wnt3) |
---|---|---|---|
Interval Breakpoints | 96.4–129.8 Mb | 129.8–154.4 Mb | 69.4–103.7 Mb |
Interval size | 33 Mb | 25 Mb | 34 Mb |
Number of annotated genes | 470 | 461 | 905 |
Pedigrees screened | 530 | 551 | 785 |
Lethal lines | 11 | 19 | 59 |
Other viable phenotypes | 0 | 4 | 32 |
Total mutations | 11 | 23 | 91 |
Mutations/Mb | 0.33 | 0.92 | 2.68 |
Homogeneity of samplesa | 3.913, p < 0.05 | 22.8, p < 0.001 | 37.2, p < 0.001 |
Frequency of mutations mapping outside of the balancer region | 1 in 5.4 | 1 in 4.8 | 1 in 4.2 |
Literature Reference | This report | Hentges et al. 2006 [4] | Kile et al. 2003 [5] |