From: A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines
Gene | Published phenotype |
---|---|
Pre-implantation | |
Cdca8 Cdc20 Faf1 | embryos present at E3.5 but fail to form fully expanded blastocyst [8] embryos arrested at the two cell stage [39] embryos arrested at the two cell stage [12] |
Nasp | at E3.5, blastocyts are smaller with fewer cells [13] |
E5.5–E8.5 | |
Foxd3 | failure to gastrulate, finger-like extensions seen at distal tip [14] |
Gjb3 | |
Hdac1 | embryonic lethality before turning of embryo, growth retarded after E7.5 [17, 18] |
Macf1 | lethality before somite formation [19] |
Ncdn | resorption was evident prior to E6.5 [20] |
Urod | lethality before somite formation, no fetuses at E7.5–E9.5 [21] |
E9.5–E12.5 | |
Bmp8b | smaller than expected, delayed, die by E9.25 [22] |
Ppap2b | |
Slc2a1 | prenatal lethality E10–E14, reduced embryo size, overall developmental delay [25] |
Stil | lethality around E10.5, abnormal left-right axis patterning, growth retardation abnormal neural tube morphology and development [26] |
Tal1 | lethality at E8.5–E10.5, arrested development, cardiovascular defects, defects in |
 | hematopoiesis, distended pericardial sacs, pale and necrotic [9] |
E13.5–E18.5 | |
Dhcr24 | some die before birth, others smaller with less adipose tissue, decreased cholesterol levels, male and female infertility [27] |
Gjb5 | death at E11.5–E14.5, smaller with placental defects [28] |
Marcksl1 | neural tube [29] |
Mtf1 | embryos die around E14 due to liver degeneration [30] |
Ssbp3 | prenatal lethality, abnormal head development [31] |
Tie1 | death before E13.5, respiratory, cardiovascular, skin defects [32] |
Ybx1 | lethality E13.5-just after birth, reduced embryo size, craniofacial defects, abnormal neural tube closure [33] |
Peri-natal | |
Jak1 | neonates smaller with abnormal B and T cell development [34] |
Khdrbs1 | 2/3 die at birth, and the survivors live well into adulthood [35] |
Nfia | lethality at P0, survivors have severe brain abnormalities [36] |
Pou3f1 | die within a few hours of birth due to respiratory defects [37] |
Ror1 | die just after birth with abnormal blood chemistry and respiratory system defects [38] |
Slc6a9 | die just after birth with severe motor and respiratory defects[40] |
Post-natal | |
Dab1 | lethality at 20–30 days, decreased leptin levels, nervous system defects including ataxia, abnormal brain morphology [10, 11] |
Dmbx1 | lethality before P9, smaller, little or no milk in stomachs [7, 41, 42] |