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Table 3 Determining the Time of Death of Chromosome 4 (117–281) Lethal Mutants

From: A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines

Line Name

# Litters examined

Stages examined

# Homozygous mutantsa

# Heterozygous mutants or balancer monozygotes

# Resorbed embryos

Unable to determineb

Stage of death

Notes on mutants

l4Jus19

1

E12.5

2

2

8

0

E9.5–12.5

Dead at E12.5

l4Jus22

1

E11.5

0

7

1

0

Not determined

 

l4Jus23

4

E11.5–12.5

0

21

16

0

Before E11.5

 

l4Jus24

6

E7.5–13.5

0

23

11

1

Before E7.5

 

l4Jus25

3

E10.5, E12.5

3

17

7

0

E9.5–12.5

Smaller, cardiac defects

l4Jus26

6

E8.5–12.5

5

30

15

1

E5.5–7.5

Smaller, developmental delay

l4Jus27

8

E7.5–12.5

0

38

5

4

Before E8.5

 

l4Jus28

15

E8.5–10.5, E12.5

25

89

3

0

E9.5–12.5

Vascular defects

l4Jus29

2

E8.5, E12.5

3

11

2

0

Before E7.5

Fail to grow after implantation

l4Jus30

7

E10.5–12.5

16

45

5

0

E9.5–12.5

Craniofacial defects

l4Jus31

8

E9.5, E12.5, P11–25

15

36

6

0

Post-natal

Neurological defects

  1. a After E12.5 mutant embryos were identified by lack of eye pigment and heterozygous mutants or balancer homozygotes were identified by eye pigmentation
  2. b Embryos were lost during the dissection